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Metabolic engineering of Saccharomyces cerevisiae for production of very long chain fatty acid-derived chemicals

Authors :
Tao Yu
Yongjin J. Zhou
Leonie Wenning
Quanli Liu
Anastasia Krivoruchko
Verena Siewers
Jens Nielsen
Florian David
Source :
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Publication Year :
2017
Publisher :
Nature Portfolio, 2017.

Abstract

Production of chemicals by microbial fermentation is an economical alternative to chemical synthesis. Here the authors re-engineer the yeastS. cerevisiaeto produce the very long chain fatty alcohol docosanol by expressing a heterologous Mycobacteria fatty acid synthase and a specific fatty acid reductase.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
8
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.36f3a67ebbcd46798748b17bc28b8b18
Document Type :
article
Full Text :
https://doi.org/10.1038/ncomms15587