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A non-canonical, interferon-independent signaling activity of cGAMP triggers DNA damage response signaling
- Source :
- Nature Communications, Vol 12, Iss 1, Pp 1-24 (2021)
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) is normally induced by innate immunity sensing for protection from pathogens. Here the authors show that cGAMP is also upstream of DNA damage signaling by activating ATM-CHK2-mediated repair pathway, while simultaneously suppressing the homology-directed repair.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 12
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.369050a7118f414592da44c95861d278
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-021-26240-9