Back to Search Start Over

Unveiling the Significance of Peroxiredoxin 6 in Central Nervous System Disorders

Authors :
Min Xue
Xiaojie Huang
Tong Zhu
Lijun Zhang
Hao Yang
Yuxian Shen
Lijie Feng
Source :
Antioxidants, Vol 13, Iss 4, p 449 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Peroxiredoxin 6 (Prdx6), a unique 1-Cys member of the peroxiredoxin family, exhibits peroxidase activity, phospholipase activity, and lysophosphatidylcholine acyltransferase (LPCAT) activity. Prdx6 has been known to be an important enzyme for the maintenance of lipid peroxidation repair, cellular metabolism, inflammatory signaling, and antioxidant damage. Growing research has demonstrated that the altered activity of this enzyme is linked with various pathological processes including central nervous system (CNS) disorders. This review discusses the distinctive structure, enzyme activity, and function of Prdx6 in different CNS disorders, as well as emphasizing the significance of Prdx6 in neurological disorders.

Details

Language :
English
ISSN :
20763921
Volume :
13
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Antioxidants
Publication Type :
Academic Journal
Accession number :
edsdoj.363f6467c9734f08b43cef337339329d
Document Type :
article
Full Text :
https://doi.org/10.3390/antiox13040449