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Intestine-specific removal of DAF-2 nearly doubles lifespan in Caenorhabditis elegans with little fitness cost
- Source :
- Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
- Publication Year :
- 2022
- Publisher :
- Nature Portfolio, 2022.
-
Abstract
- The role of lifespan-regulating protein expression in specific tissues in C. elegans is murky. Here, the authors provide clarity by inducible degradation of longevity-related proteins, demonstrating that intestinal DAF-2 is a major determinant of lifespan in the worm.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723 and 02558890
- Volume :
- 13
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.35e79ba0b0574bc1818d025588906364
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-022-33850-4