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Higher angiotensin-converting enzyme 2 (ACE2) levels in the brain of individuals with Alzheimer’s disease

Authors :
Louise Reveret
Manon Leclerc
Vincent Emond
Cyntia Tremblay
Andréanne Loiselle
Philippe Bourassa
David A. Bennett
Sébastien S. Hébert
Frédéric Calon
Source :
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-17 (2023)
Publication Year :
2023
Publisher :
BMC, 2023.

Abstract

Abstract Cognitive decline due to Alzheimer’s disease (AD) is frequent in the geriatric population, which has been disproportionately affected by the COVID-19 pandemic. In this study, we investigated the levels of angiotensin-converting enzyme 2 (ACE2), a regulator of the renin-angiotensin system and the main entry receptor of SARS-CoV-2 in host cells, in postmortem parietal cortex samples from two independent AD cohorts, totalling 142 persons. Higher concentrations of ACE2 protein (p

Details

Language :
English
ISSN :
20515960
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Acta Neuropathologica Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.35a368b7de5c46d7b1fd90b978430f40
Document Type :
article
Full Text :
https://doi.org/10.1186/s40478-023-01647-1