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The serine proteases dipeptidyl-peptidase 4 and urokinase are key molecules in human and mouse scar formation

Authors :
Vera Vorstandlechner
Maria Laggner
Dragan Copic
Katharina Klas
Martin Direder
Yiyan Chen
Bahar Golabi
Werner Haslik
Christine Radtke
Erwin Tschachler
Konrad Hötzenecker
Hendrik Jan Ankersmit
Michael Mildner
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Mechanisms triggering hypertrophic scar formation remain poorly understood. Here the authors perform scRNA-seq on mature human hypertrophic scars and developing scars in mice to identify the serine proteases dipeptidyl-peptidase 4 and urokinase as key molecules in this process.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.358e2696c34f432285e35a6424f017c0
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-26495-2