Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor

Authors :: Chengcheng Guan
Yange Niu
Si-Cong Chen
Yunlu Kang
Jing-Xiang Wu
Koji Nishi
Catherine C. Y. Chang
Ta-Yuan Chang
Tuoping Luo
Lei Chen
Source :: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Publication Year :: 2020
Publisher :: Nature Portfolio, 2020.
Abstract: Sterol O-acyltransferase 1 (SOAT1, also named ACAT1) is an endoplasmic reticulum resident enzyme which catalyzes the esterification of cholesterol to generate cholesteryl esters. Here, authors report cryo-EM structures of human SOAT1 which reveal the binding site of the competitive inhibitor CI-976.

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