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About atypical dyslipidemia variants in myocardial infarction and unstable angina

Authors :
B. M. Lipovetsky
Source :
Кардиоваскулярная терапия и профилактика, Vol 8, Iss 5, Pp 46-49 (2009)
Publication Year :
2009
Publisher :
«SILICEA-POLIGRAF» LLC, 2009.

Abstract

Aim. To analyse atypical variants of dyslipidemia (DLP) in coronary heart disease (CHD).Material and methods. The study included rehabilitation unit patients with myocardial infarction (MI). Over 5 years, 78 patients with severe hypertriglyceridemia (HTG) or selective decrease in anti-atherogenic lipoproteins were selected. The patients with the DLP phenotypes most typical for CHD (IIa, IIb) were not included in the study. Mean age of the participants was 46± 1 years. All participants were divided into three groups: with combined hyperlipidaemia (HLP) due to increased cholesterol (CH) and triglycerides (TG), but with prevalent HTG — Group I (n=24); with isolated HTG — Group II (n=23); with selective reduction in high- density lipoproteins (HDL) — Group III (n=31).Results. Group I was characterised by substantial increase in the levels of CH and TG (6,8±0,5 mmol/l); Group II — by isolated increase in TG level (4,1±0,4 mmol/l); and Group III — by selective reduction in HDL-CL concentration (0,82±0,02 mmol/l).Conclusion. Atherosclerosis and its complications might develop not only in HLP IIa and IIb, but also due to HTG or decreased anti-atherogenic lipoprotein levels. All primary DLP are hereditary, but typically they are linked to polygenic defects — i.e., are dependent on functionally important nucleotide polymorphisms in genes regulating lipid metabolism.

Details

Language :
Russian
ISSN :
17288800 and 26190125
Volume :
8
Issue :
5
Database :
Directory of Open Access Journals
Journal :
Кардиоваскулярная терапия и профилактика
Publication Type :
Academic Journal
Accession number :
edsdoj.357a82a0c00642a3ac70f275adc1c27e
Document Type :
article