Back to Search Start Over

Viral and Immunologic Factors Associated with Fatal Outcome of Patients with Severe Fever with Thrombocytopenia Syndrome in Korea

Authors :
Ji-Soo Kwon
Sol Jin
Ji-Yeun Kim
Sang-Hyun Ra
Taeeun Kim
Se-Yoon Park
Min-Chul Kim
Seong-Yeon Park
Dasarang Kim
Hye-Hee Cha
Hyun-Jung Lee
Min-Jae Kim
Yong-Pil Chong
Sang-Oh Lee
Sang-Ho Choi
Yang-Soo Kim
Keun-Hwa Lee
Sun-Ho Kee
Sung-Han Kim
Source :
Viruses, Vol 13, Iss 12, p 2351 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Significant progress has been made on the molecular biology of the severe fever with thrombopenia virus (SFTSV); however, many parts of the pathophysiological mechanisms of mortality in SFTS remain unclear. In this study, we investigated virologic and immunologic factors for fatal outcomes of patients with SFTS. We prospectively enrolled SFTS patients admitted from July 2015 to October 2020. Plasma samples were subjected to SFTSV RNA RT-PCR, multiplex microbead immunoassay for 17 cytokines, and IFA assay. A total of 44 SFTS patients were enrolled, including 37 (84.1%) survivors and 7 (15.9%) non-survivors. Non-survivors had a 2.5 times higher plasma SFTSV load than survivors at admission (p < 0.001), and the viral load in non-survivors increased progressively during hospitalization. In addition, non-survivors did not develop adequate anti-SFTSV IgG, whereas survivors exhibited anti-SFTSV IgG during hospitalization. IFN-α, IL-10, IP-10, IFN-γ, IL-6, IL-8, MCP-1, MIP-1α, and G-CSF were significantly elevated in non-survivors compared to survivors and did not revert to normal ranges during hospitalization (p < 0.05). Severe signs of inflammation such as a high plasma concentration of IFN-α, IL-10, IP-10, IFN-γ, IL-6, IL-8, MCP-1, MIP-1α, and G-CSF, poor viral control, and inadequate antibody response during the disease course were associated with mortality in SFTS patients.

Details

Language :
English
ISSN :
19994915
Volume :
13
Issue :
12
Database :
Directory of Open Access Journals
Journal :
Viruses
Publication Type :
Academic Journal
Accession number :
edsdoj.35797cf6a1d4857a5cde673b4b76a61
Document Type :
article
Full Text :
https://doi.org/10.3390/v13122351