Association of HMGA2 Polymorphisms with Glioma Susceptibility in Chinese Children

Jingying Zhou,1 Pan Wang,1 Ran Zhang,2 Xiaokai Huang,1 Hanqi Dai,1 Li Yuan,3 Jichen Ruan1 1Department of Hematology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, People’s Republic of China; 2Sydney School of Public Health, The University of Sydney, Camperdown, Sydney, NSW, 2006, Australia; 3Department of Pathology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, 510623, Guangdong, People’s Republic of ChinaCorrespondence: Jichen RuanDepartment of Hematology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, 109 West Xueyuan Road, Wenzhou, 325027, Zhejiang, People’s Republic of ChinaEmail delcruanjichen@163.comLi YuanDepartment of Pathology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, 9 Jinsui Road, Guangzhou, 510623, Guangdong, People’s Republic of ChinaEmail lizzyklarck@126.comBackground: Glioma is a malignant central nervous system tumor in children, with poor outcomes and prognosis. HMGA2 is a proto-oncogene with increased expression in various malignancies.Methods: We explored the association of HMGA2 polymorphisms with glioma susceptibility in Chinese children using a case-control study (191 cases, 248 controls). HMGA2 single nucleotide polymorphisms (rs6581658 A>G; rs8756 A>C; rs968697 T>C) were genotyped using PCR-based TaqMan.Results: Increased glioma susceptibility was associated with rs6581658 A>G; AG (adjusted odds ratio (OR) = 1.71, 95% confidence interval (CI) = 1.13– 2.58, P = 0.010) or GG (adjusted OR = 3.12, 95% CI = 1.26– 7.74, P = 0.014) genotype carriers had significantly raised glioma risk compared with AA genotype carriers. The rs6581658 AG/GG (adjusted OR = 1.85, 95% CI = 1.25– 2.73, P = 0.002) and AA/GG (adjusted OR = 2.58, 95% CI = 1.05– 6.33, P = 0.038) genotypes were associated with an increased risk of glioma relative to the AA genotype. Subjects with 2– 3 risk genotypes had a significantly elevated risk (adjusted OR = 1.93, 95% CI = 1.31– 2.84, P = 0.001) relative to those with 0– 1 risk genotype.Conclusion: HMGA2 rs6581658 A>G is associated with glioma susceptibility in Chinese children.Keywords: HMGA2, polymorphism, susceptibility, glioma