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Effects of Lumbar Stabilization and Graded Activity Exercises on Selected Biochemical Mediators and Clinical Outcomes in Patients With Non-specific Chronic Low Back Pain
- Source :
- Iranian Rehabilitation Journal, Vol 21, Iss 4, Pp 663-694 (2023)
- Publication Year :
- 2023
- Publisher :
- Negah Institute for Scientific Communication, 2023.
-
Abstract
- Objectives: This study aims to investigate the effects of lumbar stabilization exercise (LSE) and graded activity exercise (GAE) on concentrations of interleukin (IL) 1A (IL1A), IL18 receptor 1 (IL18R1), IL18 receptor accessory protein (IL18RAP), IL-6, cyclooxygenase-2 (COX2), and clinical outcomes of pain intensity, disability, catastrophizing, diverting-attention, cognitive-coping and pain-reinterpretation in patients with non-specific chronic low back pain (NSCLBP). Methods: This study was a single-blind parallel trial with an adaptive trial design. Fifty-four patients with NSCLBP were randomly assigned to LSE and GAE treatment groups. Demographic and anthropometric characteristics were measured. Treatments were administered twice a week for 10 weeks. The concentrations of IL1A, IL18R1, IL18RAP, IL-6, and COX2 of patients were assessed at four time points with enzyme-linked immunosorbent assay. Pain, disability, catastrophizing, diverting attention, cognitive coping, and pain reinterpretation were assessed at three time points with valid instruments. The responsiveness of the biochemical mediators to LSE and GAE was determined with a Bayesian one-way analysis of variance (ANOVA). Data were analyzed with descriptive and inferential statistics at P1). The concentrations of IL-6 increased significantly (P0.05). Catastrophizing of patients with LSE was significantly less (P
Details
- Language :
- English
- ISSN :
- 17353602 and 17353610
- Volume :
- 21
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Iranian Rehabilitation Journal
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.350e971ae2b4b6aa23b1b7ae2d224a0
- Document Type :
- article