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Microspheres in bone regeneration: Fabrication, properties and applications

Authors :
Zhuyun Cai
Heng Jiang
Tao Lin
Ce Wang
Jun Ma
Rui Gao
Yingying Jiang
Xuhui Zhou
Source :
Materials Today Advances, Vol 16, Iss , Pp 100315- (2022)
Publication Year :
2022
Publisher :
Elsevier, 2022.

Abstract

In the last few decades, microspheres and microsphere-based scaffolds have demonstrated great potential in translational medicine. Various materials, including natural polymers, synthetic polymers, bioactive ceramics, and their composites, have been fabricated into microspheres for bone-defect repair. In this review, we summarize the specific steps and research progress of various fabrication methods for microspheres and identify the main limitations of existing techniques. The appropriate materials and surface-modification strategies that can increase the biological properties of microspheres are also described. Finally, we discuss the key application of microsphere-functionalized scaffolds for bone tissue engineering. We expect that this review will enable more future investigations that focus on the field of microsphere tissue engineering, and thus advance the development of fabrication technology and facilitate the application of microspheres for bone regeneration.

Details

Language :
English
ISSN :
25900498
Volume :
16
Issue :
100315-
Database :
Directory of Open Access Journals
Journal :
Materials Today Advances
Publication Type :
Academic Journal
Accession number :
edsdoj.34d304fe3844c67bbf202a32d3df545
Document Type :
article
Full Text :
https://doi.org/10.1016/j.mtadv.2022.100315