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Phosphocode-dependent glutamyl-prolyl-tRNA synthetase 1 signaling in immunity, metabolism, and disease
- Source :
- Experimental and Molecular Medicine, Vol 55, Iss 10, Pp 2116-2126 (2023)
- Publication Year :
- 2023
- Publisher :
- Nature Publishing Group, 2023.
-
Abstract
- Abstract Ubiquitously expressed aminoacyl-tRNA synthetases play essential roles in decoding genetic information required for protein synthesis in every living species. Growing evidence suggests that they also function as crossover mediators of multiple biological processes required for homeostasis. In humans, eight cytoplasmic tRNA synthetases form a central machinery called the multi-tRNA synthetase complex (MSC). The formation of MSCs appears to be essential for life, although the role of MSCs remains unclear. Glutamyl-prolyl-tRNA synthetase 1 (EPRS1) is the most evolutionarily derived component within the MSC that plays a critical role in immunity and metabolism (beyond its catalytic role in translation) via stimulus-dependent phosphorylation events. This review focuses on the role of EPRS1 signaling in inflammation resolution and metabolic modulation. The involvement of EPRS1 in diseases such as cancer is also discussed.
- Subjects :
- Medicine
Biochemistry
QD415-436
Subjects
Details
- Language :
- English
- ISSN :
- 20926413
- Volume :
- 55
- Issue :
- 10
- Database :
- Directory of Open Access Journals
- Journal :
- Experimental and Molecular Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.347de579b0a84d3598c442a9b0fb9b6e
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s12276-023-01094-x