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Photostable and Biocompatible Fluorescent Silicon Nanoparticles for Imaging-Guided Co-Delivery of siRNA and Doxorubicin to Drug-Resistant Cancer Cells

Authors :
Daoxia Guo
Xiaoyuan Ji
Fei Peng
Yiling Zhong
Binbin Chu
Yuanyuan Su
Yao He
Source :
Nano-Micro Letters, Vol 11, Iss 1, Pp 1-13 (2019)
Publication Year :
2019
Publisher :
SpringerOpen, 2019.

Abstract

Abstract The development of effective and safe vehicles to deliver small interfering RNA (siRNA) and chemotherapeutics remains a major challenge in RNA interference-based combination therapy with chemotherapeutics, which has emerged as a powerful platform to treat drug-resistant cancer cells. Herein, we describe the development of novel all-in-one fluorescent silicon nanoparticles (SiNPs)-based nanomedicine platform for imaging-guided co-delivery of siRNA and doxorubicin (DOX). This approach enhanced therapeutic efficacy in multidrug-resistant breast cancer cells (i.e., MCF-7/ADR cells). Typically, the SiNP-based nanocarriers enhanced the stability of siRNA in a biological environment (i.e., medium or RNase A) and imparted the responsive release behavior of siRNA, resulting in approximately 80% down-regulation of P-glycoprotein expression. Co-delivery of P-glycoprotein siRNA and DOX led to > 35-fold decrease in the half maximal inhibitory concentration of DOX in comparison with free DOX, indicating the pronounced therapeutic efficiency of the resultant nanocomposites for drug-resistant breast cancer cells. The intracellular time-dependent release behaviors of siRNA and DOX were revealed through tracking the strong and stable fluorescence of SiNPs. These data provide valuable information for designing effective RNA interference-based co-delivery carriers.

Details

Language :
English
ISSN :
23116706 and 21505551
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nano-Micro Letters
Publication Type :
Academic Journal
Accession number :
edsdoj.345fdd35a3284410b3e4fc961569f150
Document Type :
article
Full Text :
https://doi.org/10.1007/s40820-019-0257-1