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MAIT cells are activated during human viral infections

Authors :
Bonnie van Wilgenburg
Iris Scherwitzl
Edward C. Hutchinson
Tianqi Leng
Ayako Kurioka
Corinna Kulicke
Catherine de Lara
Suzanne Cole
Sirijitt Vasanawathana
Wannee Limpitikul
Prida Malasit
Duncan Young
Laura Denney
STOP-HCV consortium
Michael D. Moore
Paolo Fabris
Maria Teresa Giordani
Ye Htun Oo
Stephen M. Laidlaw
Lynn B. Dustin
Ling-Pei Ho
Fiona M. Thompson
Narayan Ramamurthy
Juthathip Mongkolsapaya
Christian B. Willberg
Gavin R. Screaton
Paul Klenerman
Source :
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Publication Year :
2016
Publisher :
Nature Portfolio, 2016.

Abstract

Mucosal Associated Invariant T cells have been implicated in response to bacterial pathogens. Here the authors show that in human viral infections, these cells are activated by IL-18 in cooperation with other pro-inflammatory cytokines, producing interferon gamma and granzyme B.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
7
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.3459afe5a047aa8c5feb665511a1eb
Document Type :
article
Full Text :
https://doi.org/10.1038/ncomms11653