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Genetic profiling in radiotherapy: a comprehensive review

Authors :
Dino Rubini
Federico Gagliardi
Vittorio Salvatore Menditti
Luca D’Ambrosio
Paolo Gallo
Ida D’Onofrio
Antonio Rosario Pisani
Angela Sardaro
Giuseppe Rubini
Salvatore Cappabianca
Valerio Nardone
Alfonso Reginelli
Source :
Frontiers in Oncology, Vol 14 (2024)
Publication Year :
2024
Publisher :
Frontiers Media S.A., 2024.

Abstract

This comprehensive review explores the pivotal role of radiotherapy in cancer treatment, emphasizing the diverse applications of genetic profiling. The review highlights genetic markers for predicting radiation toxicity, enabling personalized treatment planning. It delves into the impact of genetic profiling on radiotherapy strategies across various cancer types, discussing research findings related to treatment response, prognosis, and therapeutic resistance. The integration of genetic profiling is shown to transform cancer treatment paradigms, offering insights into personalized radiotherapy regimens and guiding decisions in cases where standard protocols may fall short. Ultimately, the review underscores the potential of genetic profiling to enhance patient outcomes and advance precision medicine in oncology.

Details

Language :
English
ISSN :
2234943X
Volume :
14
Database :
Directory of Open Access Journals
Journal :
Frontiers in Oncology
Publication Type :
Academic Journal
Accession number :
edsdoj.3418dc00944e3b0544cddc0f46f6e
Document Type :
article
Full Text :
https://doi.org/10.3389/fonc.2024.1337815