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Phosphomethylpyrimidine Synthase (ThiC): Trapping of Five Intermediates Provides Mechanistic Insights on a Complex Radical Cascade Reaction in Thiamin Biosynthesis

Authors :
Vishav Sharma
Dmytro Fedoseyenko
Sumedh Joshi
Sameh Abdelwahed
Tadhg P. Begley
Source :
ACS Central Science, Vol 10, Iss 5, Pp 988-1000 (2024)
Publication Year :
2024
Publisher :
American Chemical Society, 2024.

Subjects

Subjects :
Chemistry
QD1-999

Details

Language :
English
ISSN :
23747951
Volume :
10
Issue :
5
Database :
Directory of Open Access Journals
Journal :
ACS Central Science
Publication Type :
Academic Journal
Accession number :
edsdoj.340201aec237413da05fbeb8e9db94bc
Document Type :
article
Full Text :
https://doi.org/10.1021/acscentsci.4c00125