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Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection

Authors :
Khadija Khan
Farina Karim
Yashica Ganga
Mallory Bernstein
Zesuliwe Jule
Kajal Reedoy
Sandile Cele
Gila Lustig
Daniel Amoako
Nicole Wolter
Natasha Samsunder
Aida Sivro
James Emmanuel San
Jennifer Giandhari
Houriiyah Tegally
Sureshnee Pillay
Yeshnee Naidoo
Matilda Mazibuko
Yoliswa Miya
Nokuthula Ngcobo
Nithendra Manickchund
Nombulelo Magula
Quarraisha Abdool Karim
Anne von Gottberg
Salim S. Abdool Karim
Willem Hanekom
Bernadett I. Gosnell
COMMIT-KZN Team
Richard J. Lessells
Tulio de Oliveira
Mahomed-Yunus S. Moosa
Alex Sigal
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-7 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Emerging SARS-CoV-2 Omicron sub-lineages BA.4 and BA.5 raise concerns about potential immune evasion. Here, Khan et al. show that both BA.4 and BA.5 are able to escape immune response induced by prior BA.1 infection, but that this effect is less pronounced in vaccinated individuals.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.33f1969012c445a9979f3a62e870904
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-32396-9