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Impairment of PARK14-dependent Ca2+ signalling is a novel determinant of Parkinson’s disease
- Source :
- Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
- Publication Year :
- 2016
- Publisher :
- Nature Portfolio, 2016.
-
Abstract
- PLA2g6 regulates store-operated Ca2+ entry and is linked to Parkinson’s disease. Here, Zhou et al find faulty PLA2g6-dependent Ca2+signaling in idiopathic PD patients, and show that its impairment triggers autophagic dysfunction and loss of dopaminergic neurons in a new PLA2g6 ex2KO mouse model.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 7
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.33e1f0f92a0c4245b5c7415b37aee723
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/ncomms10332