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Comparison of physicochemical properties of suppositories containing starch hydrolysates
- Source :
- Saudi Pharmaceutical Journal, Vol 25, Iss 3, Pp 365-369 (2017)
- Publication Year :
- 2017
- Publisher :
- Elsevier, 2017.
-
Abstract
- The purpose of this work was to determine the effect of starch hydrolysates (SH) on the physicochemical properties of suppositories. The study was conducted with suppositories with acetaminophen (AAP) a typical antipyretic analgesic, as model drug on lipophilic (cocoa butter) and hydrophilic base (polyethylene glycol 1500 + 400). The suppositories with and without the addition of SH were examined for physicochemical tests according to European Pharmacopoeia 8th edition (Ph. Eur.): the uniformity of mass of single-dose preparation test, the softening time determination of lipophilic suppositories test, the disintegration of suppositories test, and dissolution test with flow-through apparatus. The results confirm the possibility of using starch hydrolysates as a cheap and safe addition to modify physicochemical properties of suppositories.
Details
- Language :
- English
- ISSN :
- 13190164
- Volume :
- 25
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Saudi Pharmaceutical Journal
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.33cf8e1616ba4e3da7182b9c7325384f
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.jsps.2016.09.004