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Comparative molecular genomic analyses of a spontaneous rhesus macaque model of mismatch repair-deficient colorectal cancer.
- Source :
- PLoS Genetics, Vol 18, Iss 4, p e1010163 (2022)
- Publication Year :
- 2022
- Publisher :
- Public Library of Science (PLoS), 2022.
-
Abstract
- Colorectal cancer (CRC) remains the third most common cancer in the US with 15% of cases displaying Microsatellite Instability (MSI) secondary to Lynch Syndrome (LS) or somatic hypermethylation of the MLH1 promoter. A cohort of rhesus macaques from our institution developed spontaneous mismatch repair deficient (MMRd) CRC with a notable fraction harboring a pathogenic germline mutation in MLH1 (c.1029C
Details
- Language :
- English
- ISSN :
- 15537390 and 15537404
- Volume :
- 18
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- PLoS Genetics
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.3345afdd7e5447958a5094fe6c001467
- Document Type :
- article
- Full Text :
- https://doi.org/10.1371/journal.pgen.1010163