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Endogenous and Exogenous Antioxidants as Agents Preventing the Negative Effects of Contrast Media (Contrast-Induced Nephropathy)

Authors :
Ina G. Panova
Alexander S. Tatikolov
Source :
Pharmaceuticals, Vol 16, Iss 8, p 1077 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

The use of conventional contrast media for diagnostic purposes (in particular, Gd-containing and iodinated agents) causes a large number of complications, the most common of which is contrast-induced nephropathy. It has been shown that after exposure to contrast agents, oxidative stress often occurs in patients, especially in people suffering from various diseases. Antioxidants in the human body can diminish the pathological consequences of the use of contrast media by suppressing oxidative stress. This review considers the research studies on the role of antioxidants in preventing the negative consequences of the use of contrast agents in diagnostics (mainly contrast-induced nephropathy) and the clinical trials of different antioxidant drugs against contrast-induced nephropathy. Composite antioxidant/contrast systems as theranostic agents are also considered.

Details

Language :
English
ISSN :
14248247
Volume :
16
Issue :
8
Database :
Directory of Open Access Journals
Journal :
Pharmaceuticals
Publication Type :
Academic Journal
Accession number :
edsdoj.32ff0f492551400fb61b155440643b3d
Document Type :
article
Full Text :
https://doi.org/10.3390/ph16081077