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Changes of pulse wave transit time after haemodynamic manoeuvres in healthy adults: a prospective randomised observational trial (PWTT volunteer study)
- Source :
- BJA Open, Vol 11, Iss , Pp 100291- (2024)
- Publication Year :
- 2024
- Publisher :
- Elsevier, 2024.
-
Abstract
- Background: Pulse wave transit time (PWTT) shows promise for monitoring intravascular fluid status intraoperatively. Presently, it is unknown how PWTT mirrors haemodynamic variables representing preload, inotropy, or afterload. Methods: PWTT was measured continuously in 24 adult volunteers. Stroke volume was assessed by transthoracic echocardiography. Volunteers underwent four randomly assigned manoeuvres: ‘Stand-up’ (decrease in preload), passive leg raise (increase in preload), a ‘step-test’ (adrenergic stimulation), and a ‘Valsalva manoeuvre’ (increase in intrathoracic pressure). Haemodynamic measurements were performed before and 1 and 5 min after completion of each manoeuvre. Correlations between PWTT and stroke volume were analysed using the Pearson correlation coefficient. Results: ‘Stand-up’ caused an immediate increase in PWTT (mean change +55.9 ms, P-value
Details
- Language :
- English
- ISSN :
- 27726096
- Volume :
- 11
- Issue :
- 100291-
- Database :
- Directory of Open Access Journals
- Journal :
- BJA Open
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.32b461d992e7489db3b49a11d4074342
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.bjao.2024.100291