Changes in complement activation products after anti-VEGF injection for choroidal neovascularization in age-related macular degeneration and pachychoroid disease

Authors :: Keiichiro Tanaka
Yasuharu Oguchi
Tomoko Omori
Yumi Ishida
Hiroaki Shintake
Ryutaro Tomita
Akihito Kasai
Masashi Ogasawara
Yukinori Sugano
Kanako Itagaki
Akira Ojima
Takeshi Machida
Hideharu Sekine
Tetsuju Sekiryu
Source :: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Publication Year :: 2021
Publisher :: Nature Portfolio, 2021.
Abstract: Abstract We evaluated changes in the complement system resulting from anti-vascular endothelial growth factor (VEGF) in eyes with age-related choroidal neovascularization (CNV) including neovascular age-related macular degeneration, pachychoroid neovasculopathy, and polypoidal choroidal neovasculopathy. We measured the concentrations of the complement activation products (C3a, C4a), VEGF, and monocyte chemotactic protein-1 in the aqueous humor during intravitreal anti-VEGF injections for CNV. The VEGF level decreased significantly (P

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