Back to Search
Start Over
Insulin resistance mediates high-fat diet-induced pulmonary fibrosis and airway hyperresponsiveness through the TGF-β1 pathway
- Source :
- Experimental and Molecular Medicine, Vol 51, Iss 5, Pp 1-12 (2019)
- Publication Year :
- 2019
- Publisher :
- Nature Publishing Group, 2019.
-
Abstract
- Obesity: A trigger for asthma onset Insulin resistance may be an important causative factor underlying the increased risk of asthma and other respiratory issues in obese individuals. Obesity doubles the likelihood of developing asthma, with symptoms that are more difficult to control than in non-obese patients. The connection between these conditions is poorly understood, but researchers led by Jung-Won Park, Yonsei University College of Medicine, Seoul, South Korea, have identified a potential mechanism. They demonstrated that a signaling molecule called TGF-β1 contributes to airway sensitivity and tissue scarring in a mouse model of diet-induced obesity. Subsequent experiments showed that treatment with insulin also gives rise to increased TGF-β1 production in the mouse lung. Since insulin resistance is a common feature of obesity, resulting in abnormally high levels of circulating insulin, this could also account for the increased risk of respiratory problems.
- Subjects :
- Medicine
Biochemistry
QD415-436
Subjects
Details
- Language :
- English
- ISSN :
- 12263613 and 20926413
- Volume :
- 51
- Issue :
- 5
- Database :
- Directory of Open Access Journals
- Journal :
- Experimental and Molecular Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.32796a098a7f46b3b294fe909811cb02
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s12276-019-0258-7