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Knowledge Network Embedding of Transcriptomic Data from Spaceflown Mice Uncovers Signs and Symptoms Associated with Terrestrial Diseases

Authors :
Charlotte A. Nelson
Ana Uriarte Acuna
Amber M. Paul
Ryan T. Scott
Atul J. Butte
Egle Cekanaviciute
Sergio E. Baranzini
Sylvain V. Costes
Source :
Life, Vol 11, Iss 1, p 42 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

There has long been an interest in understanding how the hazards from spaceflight may trigger or exacerbate human diseases. With the goal of advancing our knowledge on physiological changes during space travel, NASA GeneLab provides an open-source repository of multi-omics data from real and simulated spaceflight studies. Alone, this data enables identification of biological changes during spaceflight, but cannot infer how that may impact an astronaut at the phenotypic level. To bridge this gap, Scalable Precision Medicine Oriented Knowledge Engine (SPOKE), a heterogeneous knowledge graph connecting biological and clinical data from over 30 databases, was used in combination with GeneLab transcriptomic data from six studies. This integration identified critical symptoms and physiological changes incurred during spaceflight.

Details

Language :
English
ISSN :
20751729
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Life
Publication Type :
Academic Journal
Accession number :
edsdoj.327389693b4a0681912ce532aa710d
Document Type :
article
Full Text :
https://doi.org/10.3390/life11010042