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Tyrosinase inhibitory components from Aloe vera and their antiviral activity
- Source :
- Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 78-83 (2017)
- Publication Year :
- 2017
- Publisher :
- Taylor & Francis Group, 2017.
-
Abstract
- A new compound, 9-dihydroxyl-2'-O-(Z)-cinnamoyl-7-methoxy-aloesin (1), and eight known compounds (2–9) were isolated from Aloe vera. Their structures were elucidated using 1D/2D nuclear magnetic resonance and mass spectra. Compound 9 exhibited reversible competitive inhibitory activity against the enzyme tyrosinase, with an IC50 value of 9.8 ± 0.9 µM. A molecular simulation revealed that compound 9 interacts via hydrogen bonding with residues His244, Thr261, and Val283 of tyrosinase. Additionally, compounds 3 and 7 were shown by half-leaf assays to exhibit inhibitory activity towards Pepper mild mottle virus.
Details
- Language :
- English
- ISSN :
- 14756366 and 14756374
- Volume :
- 32
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Enzyme Inhibition and Medicinal Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.32732569900d450b847dce81bba39f7d
- Document Type :
- article
- Full Text :
- https://doi.org/10.1080/14756366.2016.1235568