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BORDER proteins protect expression of neighboring genes by promoting 3′ Pol II pausing in plants

Authors :
Xuhong Yu
Pascal G. P. Martin
Scott D. Michaels
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

In plants, 3′ Pol II pausing helps prevent transcriptional interference. Here the authors provide evidence that BORDER proteins are enriched in intergenic regions and inhibit transcriptional interference between closely spaced genes by preventing RNA polymerase from intruding into the promoters of nearby downstream genes.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.32344f99e4f9892623ebc478613c3
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-019-12328-w