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A Rare Case of Invasive Thyroid Aspergillosis Revealed on 18F-FDG-PET/CT

Authors :
Ayoub Jaafari
Sohaïb Mansour
Laetitia Lebrun
Keitiane Kaefer
Rachid Attou
Source :
Diagnostics, Vol 14, Iss 13, p 1451 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Invasive aspergillosis (IA) represents a common form of fungal infection caused by various species of Aspergillus that most frequently affect immunocompromised patients. Typically, this disease occurs preferentially in high-risk groups including patients infected with the human immunodeficiency virus (HIV), patients with leukemia, patients with autoimmune diseases, and organ transplant patients undergoing medical immunosuppression. Considered the second most common cause of opportunistic fungal infection in humans after Candida albicans, this pathogen predominantly affects the lungs, but it may also spread by a hematogenous route to various organs and have a heterogeneous presentation. Owing to its high iodine levels, high perfusion, and enclosed capsule, the thyroid gland is considered to have a lower susceptibility to microbial invasion, and it is fairly uncommon to find associated infectious nodules. In metabolic imaging, 18F-FDG-PET/CT has become increasingly useful for detecting a wide range of infectious and inflammatory diseases and is already the gold standard for certain indications. According to the literature, no studies of hypermetabolic nodular thyroid aspergillosis on 18F-FDG-PET/CT confirmed on histology have yet been reported. Here, we report the first case of a patient with a heterogeneous presentation of IA and the presence of a hypermetabolic nodule in the thyroid with a surprising result.

Details

Language :
English
ISSN :
20754418
Volume :
14
Issue :
13
Database :
Directory of Open Access Journals
Journal :
Diagnostics
Publication Type :
Academic Journal
Accession number :
edsdoj.32334522fc64b0dbb17fc4cb727a5a0
Document Type :
article
Full Text :
https://doi.org/10.3390/diagnostics14131451