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Polycystic Ovary Syndrome and Ferroptosis: Following Ariadne’s Thread

Authors :
Styliani Geronikolou
Athanasia Pavlopoulou
Ioannis Koutelekos
Dimitrios Kalogirou
Flora Bacopoulou
Dennis V. Cokkinos
Source :
Biomedicines, Vol 12, Iss 10, p 2280 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Background: Recent literature suggests that ferroptosis (FPT) may be a key player in polycystic ovary syndrome (PCOS) pathogenesis, but the underlying mechanism(s) remain(s) unclear. Aim: Therefore, herein, we made an effort to reproduce the molecular signature of the syndrome by including FPT and exploring novel drug targets for PCOS. Methods: (a) Our previously constructed PCOS interactions molecular network was extended with the addition of FPT–associated genes (interaction score above 0.7) and (b) gene set enrichment analysis was performed so as to detect over-represented KEGG pathways. Results: The updated interactome includes 140 molecules, 20 of which are predicted/novel, with an interaction score of 7.3, and 12 major hubs. Moreover, we identified 16 over-represented KEGG pathways, with FPT being the most overexpressed pathway. The FPT subnetwork is connected with the PCOS network through KDM1A. Conclusions: FPT cell death is involved in PCOS development, as its major hub TP53 was shown to be the most important hub in the whole PCOS interactome, hence representing a prioritized drug target.

Details

Language :
English
ISSN :
22279059
Volume :
12
Issue :
10
Database :
Directory of Open Access Journals
Journal :
Biomedicines
Publication Type :
Academic Journal
Accession number :
edsdoj.320f1a9ee4184bc7980bd342751d3d67
Document Type :
article
Full Text :
https://doi.org/10.3390/biomedicines12102280