Back to Search Start Over

Mesenchymal Stem Cells: Allogeneic MSC May Be Immunosuppressive but Autologous MSC Are Dysfunctional in Lupus Patients

Authors :
Rui-Juan Cheng
An-Ji Xiong
Yan-Hong Li
Shu-Yue Pan
Qiu-Ping Zhang
Yi Zhao
Yi Liu
Tony N. Marion
Source :
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Publication Year :
2019
Publisher :
Frontiers Media S.A., 2019.

Abstract

Mesenchymal stem cells (MSCs) have a potently immunosuppressive capacity in both innate and adaptive immune responses. Consequently, MSCs transplantation has emerged as a potential beneficial therapy for autoimmune diseases even though the mechanisms underlying the immunomodulatory activity of MSCs is incompletely understood. Transplanted MSCs from healthy individuals with no known history of autoimmune disease are immunosuppressive in systemic lupus erythematosus (SLE) patients and can ameliorate SLE disease symptoms in those same patients. In contrast, autologous MSCs from SLE patients are not immunosuppressive and do not ameliorate disease symptoms. Recent studies have shown that MSCs from SLE patients are dysfunctional in both proliferation and immunoregulation and phenotypically senescent. The senescent phenotype has been attributed to multiple genes and signaling pathways. In this review, we focus on the possible mechanisms for the defective phenotype and function of MSCs from SLE patients and summarize recent research on MSCs in autoimmune diseases.

Details

Language :
English
ISSN :
2296634X
Volume :
7
Database :
Directory of Open Access Journals
Journal :
Frontiers in Cell and Developmental Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.31f752ff0c9f4f56a4b889e29d6fe620
Document Type :
article
Full Text :
https://doi.org/10.3389/fcell.2019.00285