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Sex Differences and Bmal1/Acetylcholine- or Bmal1/Noradrenaline-Mediated Effects of Blue Light Irradiation on Dextran-Sodium-Sulfate-Induced Ulcerative Colitis Model Mice

Authors :
Keiichi Hiramoto
Sayaka Kubo
Keiko Tsuji
Daijiro Sugiyama
Hideo Hamano
Source :
Gastrointestinal Disorders, Vol 6, Iss 3, Pp 720-732 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Humans are exposed to significant amounts of blue light from computers and smartphones. However, the effects of blue light on ulcerative colitis remain unclear. In this study, we assessed blue-light-irradiation-induced alterations in colonic symptoms using a dextran sodium sulfate (DSS)-induced ulcerative colitis model mice. Both male and female institute of cancer research (ICR) mice were administered DSS (5%) ad libitum for 5 days while irradiated with 40 kJ/m2 blue light daily. Additionally, tranexamic acid (TA) was administered daily throughout the study. Male mice treated with DSS/blue light exhibited exacerbated colitis compared to those treated with DSS alone. In contrast, female mice treated with DSS/blue light exhibited enhanced symptoms compared to those treated with DSS alone. Additionally, in male mice exposed to blue light, the clock/brain and muscle Arndt-like 1 (Bma1)/noradrenaline/macrophage or beta2-adrenergic receptor (β2-AR) pathways were activated. In female mice, the Bmal1/acetylcholine/macrophage/nicotinic acetylcholine receptor alpha 7 (α7nAChR) pathway was activated. These findings highlight sex differences in the effects of blue light on DSS-induced ulcerative colitis. Moreover, the worsening of symptoms in males was ameliorated through TA administration.

Details

Language :
English
ISSN :
26245647
Volume :
6
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Gastrointestinal Disorders
Publication Type :
Academic Journal
Accession number :
edsdoj.31d83b31a784159a66c034bb50baaaa
Document Type :
article
Full Text :
https://doi.org/10.3390/gidisord6030048