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Antibody affinity maturation and plasma IgA associate with clinical outcome in hospitalized COVID-19 patients

Authors :
Juanjie Tang
Supriya Ravichandran
Youri Lee
Gabrielle Grubbs
Elizabeth M. Coyle
Laura Klenow
Hollie Genser
Hana Golding
Surender Khurana
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

SARS-CoV2 infection has been linked to a wide range of clinical severities and the immunopathology is still under intense scrutiny. Here, the authors uncover an association of antibody affinity maturation and plasma IgA levels with clinical outcome in patients with COVID-19 disease.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.31cff301b7dd4bd78c29bf2e37eef897
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-21463-2