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A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition
- Source :
- Molecular Pain, Vol 3, Iss 1, p 40 (2007)
- Publication Year :
- 2007
- Publisher :
- SAGE Publishing, 2007.
-
Abstract
- Abstract Mechanical hyperalgesia is a clinically-relevant form of pain sensitization that develops through largely unknown mechanisms. TRPA1, a Transient Receptor Potential ion channel, is a sensor of pungent chemicals that may play a role in acute noxious mechanosensation and cold thermosensation. We have developed a specific small molecule TRPA1 inhibitor (AP18) that can reduce cinnameldehyde-induced nociception in vivo. Interestingly, AP18 is capable of reversing CFA-induced mechanical hyperalgesia in mice. Although TRPA1-deficient mice develop normal CFA-induced hyperalgeisa, AP18 is ineffective in the knockout mice, consistent with an on-target mechanism. Therefore, TRPA1 plays a role in sensitization of nociception, and that compensation in TRPA1-deficient mice masks this requirement.
Details
- Language :
- English
- ISSN :
- 17448069
- Volume :
- 3
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Molecular Pain
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.31b1de3780da4111ab30dcc92b8b37de
- Document Type :
- article
- Full Text :
- https://doi.org/10.1186/1744-8069-3-40