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Late-Onset Bloodstream Infection and Perturbed Maturation of the Gastrointestinal Microbiota in Premature Infants.

Authors :
Alexander G Shaw
Kathleen Sim
Paul Randell
Michael J Cox
Zoë E McClure
Ming-Shi Li
Hugo Donaldson
Paul R Langford
William O C M Cookson
Miriam F Moffatt
J Simon Kroll
Source :
PLoS ONE, Vol 10, Iss 7, p e0132923 (2015)
Publication Year :
2015
Publisher :
Public Library of Science (PLoS), 2015.

Abstract

BACKGROUND:Late-onset bloodstream infection (LO-BSI) is a common complication of prematurity, and lack of timely diagnosis and treatment can have life-threatening consequences. We sought to identify clinical characteristics and microbial signatures in the gastrointestinal microbiota preceding diagnosis of LO-BSI in premature infants. METHOD:Daily faecal samples and clinical data were collected over two years from 369 premature neonates (

Subjects

Subjects :
Medicine
Science

Details

Language :
English
ISSN :
19326203
Volume :
10
Issue :
7
Database :
Directory of Open Access Journals
Journal :
PLoS ONE
Publication Type :
Academic Journal
Accession number :
edsdoj.316d48b9fb04e33bec7607229731e69
Document Type :
article
Full Text :
https://doi.org/10.1371/journal.pone.0132923