Back to Search Start Over

Clinicopathological characteristics of mucin phenotype and its relation to the malignant potential in early differentiated gastric adenocarcinoma

Authors :
Takanobu Akaishi
Tadashi Yoshizawa
Satoko Morohashi
Shintaro Goto
Takahiro Muroya
Harue Akasaka
Kenichi Hakamada
Hiroshi Kijima
Source :
European Journal of Inflammation, Vol 19 (2021)
Publication Year :
2021
Publisher :
SAGE Publishing, 2021.

Abstract

Objectives Mucin phenotype is a tool to classify gastric cancer, but the relationship between mucin phenotype and its malignancy is still controversial. This study aimed to clarify the relationship between mucin phenotype and the malignant potential of gastric cancer. Methods A total of 82 cases of early-stage differentiated adenocarcinoma (submucosal invasion cases) obtained from surgeries were studied by immunohistochemistry. Gastric mucin phenotype and E-cadherin expression were analyzed in the mucosal and submucosal layer. E-cadherin expression was analyzed by using imaging software (ImageJ) for objective data analysis. Furthermore, the mucin phenotypic shift was analyzed from mucosa to submucosa. Results We found that: (1) tumors with intestinal mucin phenotype had statistically more venous invasion in the submucosal lesion; (2) tumors with an intestinal phenotype that showed venous invasion in the submucosal lesion had a higher percentage of tumors that showed loss of phenotype; (3) no dominant change in E-cadherin expression was observed from the mucosa to submucosa. Conclusion Tumors with loss of phenotype and submucosal intestinal phenotype showed predominantly more venous invasion, so examining the identification of phenotypes and phenotype shifts can be expected to be a factor that influences treatment strategies after endoscopic treatment or after surgical resection.

Subjects

Subjects :
Medicine

Details

Language :
English
ISSN :
20587392
Volume :
19
Database :
Directory of Open Access Journals
Journal :
European Journal of Inflammation
Publication Type :
Academic Journal
Accession number :
edsdoj.3168b2cff3ae47fb808fbb78e727ec03
Document Type :
article
Full Text :
https://doi.org/10.1177/20587392211054037