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Ultrastructural visualization of 3D chromatin folding using volume electron microscopy and DNA in situ hybridization
- Source :
- Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
- Publication Year :
- 2020
- Publisher :
- Nature Portfolio, 2020.
-
Abstract
- The genome is folded in 3-dimensions, though the lack of robust ultra-resolution imaging makes this difficult to visualise. Here, the authors present 3D-EMISH that combines serial block-face scanning electron microscopy with in situ hybridization.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 11
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.314efe399d9e425fbc4fd722009456ec
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-020-15987-2