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Enzymatic one-step ring contraction for quinolone biosynthesis
- Source :
- Nature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
- Publication Year :
- 2018
- Publisher :
- Nature Portfolio, 2018.
-
Abstract
- Viridicatin is a fungal alkaloid. Here, the authors identify and characterize the cyclopenase that catalyzes the last step of its biosynthesis in Aspergillus nidulans, the conversion of cyclopenin to viridicatin, and find that the reaction proceeds via an unusual elimination mechanism.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 9
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.314b137eb8e447180aa93d7b1b86b62
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-018-05221-5