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The Mechanism of Coronary Artery Calcification in Centrally Obese Non-Diabetic Men: Study on The Interaction of Leptin, Free Leptin Index, Adiponectin, hs-C Reactive Protein, Bone Morphogenetic Protein-2 and Matrix Gla Protein
- Source :
- MCBS (Molecular and Cellular Biomedical Sciences), Vol 4, Iss 2, Pp 88-93 (2020)
- Publication Year :
- 2020
- Publisher :
- Cell and BioPharmaceutical Institute, 2020.
-
Abstract
- Background: The calcium in the artery was thought to be the result of the imbalance or dysregulation of the promoter and inhibitor cytokines influenced by various subclinical and clinical conditions. This study aimed to investigate the interaction between central obesity, as an early subclinical condition, also known as a chronic low grade inflammation condition and coronary artery calcium (CAC) in non-diabetic population including the underlying pathomechanisms of a CAC in the early stage of atherosclerosis. Materials and Methods: This was a cross-sectional pathway analysis study enrolling 60 central obesity non-diabetic men that underwent coronary calcium score scan, anthropometrics and biomarker assays. Results: There was a positive correlation between increasing free leptin index/adiponectin (FLI/A) ratio and CAC (r=0.297; p
- Subjects :
- Pathology
RB1-214
Biochemistry
QD415-436
Subjects
Details
- Language :
- English
- ISSN :
- 25274384 and 25273442
- Volume :
- 4
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- MCBS (Molecular and Cellular Biomedical Sciences)
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.3146bc54be44eb94ac86f506194983
- Document Type :
- article
- Full Text :
- https://doi.org/10.21705/mcbs.v4i2.104