MANF regulates hypothalamic control of food intake and body weight

Authors :: Su Yang
Huiming Yang
Renbao Chang
Peng Yin
Yang Yang
Weili Yang
Shanshan Huang
Marta A. Gaertig
Shihua Li
Xiao-Jiang Li
Source :: Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Publication Year :: 2017
Publisher :: Nature Portfolio, 2017.
Abstract: MANF is a neurotrophic factor that is secreted but also mediates the unfolded protein response acting intracellularly. Here, the authors show that MANF expression in the brain is influenced by nutritional cues, and hypothalamic MANF influences food intake and systemic energy homeostasis.

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