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A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

Authors :
Sofie Voet
Conor Mc Guire
Nora Hagemeyer
Arne Martens
Anna Schroeder
Peter Wieghofer
Carmen Daems
Ori Staszewski
Lieselotte Vande Walle
Marta Joana Costa Jordao
Mozes Sze
Hanna-Kaisa Vikkula
Delphine Demeestere
Griet Van Imschoot
Charlotte L. Scott
Esther Hoste
Amanda Gonçalves
Martin Guilliams
Saskia Lippens
Claude Libert
Roos E. Vandenbroucke
Ki-Wook Kim
Steffen Jung
Zsuzsanna Callaerts-Vegh
Patrick Callaerts
Joris de Wit
Mohamed Lamkanfi
Marco Prinz
Geert van Loo
Source :
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Publication Year :
2018
Publisher :
Nature Portfolio, 2018.

Abstract

As resident macrophages of the brain, microglia are important for neuroinflammatory responses. This work shows that nuclear factor kappa B regulatory protein A20 is important for microglia activation and regulation during inflammation of the central nervous system.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
9
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.3142b0c70aa74f90b3c6f5b5f17ce066
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-018-04376-5