Effect of Some Risk Factors on Over-Anticoagulation Disorders and Bleeding in Patients Receiving Anticoagulant Therapy with Overdosage of Vitamin K Antagonist

Si Dung Chu,1,2 Minh Thi Tran2 1Haiphong - Vinhbao International General Hospital, Hai Phong City, Vietnam; 2Internal Medicine Department, Vietnam University of Traditional Medicine, Hanoi Capital, VietnamCorrespondence: Si Dung Chu, Department of Internal Medicine, Vietnam University of Traditional Medicine, Hanoi, Vietnam, Tel +84 906086168, Email sichu.bvbachmai@gmail.comObjective: Study on effect of risk factors on over-anticoagulation in patients taking anticoagulant drugs with VKAs (vitamin K antagonists).Methods: Cross-sectional descriptive, prospective research. Study on 79 patients taking anticoagulant drugs with VKAs who had an INR (International Normalized Ratio) index of more than indicated anticoagulation dose with VKAs therapy.Results: A total of 79 patients, mean age 65.65 ± 12.17 years [33:85], the elderly group is common (73.4%). Patients had hemorrhage disorders account for 22.8%. The INR index had an average value was 5.88 ± 3.0 [3.02– 23.95]; The INR> 5 level group is a higher risk of bleeding than the INR ≤ 5 level group, it’s the statistical significance (p < 0.001). The risk factors such as drugs to treat dyslipidemia, hyperthyroid, amiodarone, beta blocker, prednisone, NSAIDs (Non-steroidal anti-inflammatory), BMI (Body Mass Index), smoke and alcohol that the risk factors of increasing of bleeding when receiving anticoagulants but it’s not statistically significant yet (OR > 1, p > 0.05); These patients using coenzyme Q10 and green vegetable nutrition such as cruciferous vegetables (Brassicaceae, Asteraceae) are quite common (31.6% and 35.4%), its effect on coagulation with vitamin K and cause of the increased in risk of bleeding was statistical significantly with OR = 5.28 (CI: 1.72– 16.17, p < 0.01), and OR = 2.99 (CI: 1.01– 8.80, p < 0.05) respectively.Conclusion: Most patients in over-anticoagulation were the elderly group. Patients had hemorrhage disorders account for 22.8%. The INR> 5 level group was a higher risk of bleeding than the INR ≤ 5 level group with statistical significance. Patients using Coenzyme Q10 and green vegetable nutrition such as cruciferous vegetables (Brassicaceae, Asteraceae) are quite common, its effect on coagulation and cause of the increased risk of bleeding complication with statistical significance.Keywords: risk factors, bleeding, VKAs overdose, INR