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Yap drives the development of cardiovascular disease in patients with rheumatoid arthritis
- Source :
- Journal of Medical Biochemistry, Vol 43, Iss 2, Pp 243-249 (2024)
- Publication Year :
- 2024
- Publisher :
- Society of Medical Biochemists of Serbia, Belgrade, 2024.
-
Abstract
- Background: To assess the influence of serum level of YAP on laboratory examination findings, imaging findings and disease activity of rheumatoid arthritis patients combined cardiovascular disease (RA-CVD). Methods: RA-CVD patients (n=60), RA-nCVD patients (n=60) and healthy subjects (n=60) were recruited. Serum levels of YAP in them were detected by qRT-PCR. Their baseline characteristics were analyzed and compared. Disease activity, CVD risk factors and imaging findings in RA-CVD and RA-nCVD patients were evaluated and compared. In addition, potential influences of YAP on disease activity, CVD risk factors and imaging findings in RA-CVD patients were assessed. Results: RA-CVD patients had higher levels of ERS, anti-CCP, RF, HDL-C, CRP, FRS, BNP, LA, LVs, LVd and cIMT, and lower level of EF in comparison to RA-nCVD patients. Serum level of YAP was higher in RA-CVD patients than that of RA-nCVD patients and healthy subjects. YAP level was positively correlated to DAS28, TG, CRP, PLT, FRS, BNP and cIMT in RA-CVD patients. Conclusions: Serum level of YAP increases in RA-CVD patients. YAP is a potential factor driving the development of CVD in RA patients through regulating inflammatory response, lipid metabolism, glycometabolism and thrombosis.
- Subjects :
- rheumatoid arthritis
cardiovascular disease
yap
Biochemistry
QD415-436
Subjects
Details
- Language :
- English
- ISSN :
- 14528258 and 14528266
- Volume :
- 43
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Medical Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.311aed302de409395a6e11e7ad9838b
- Document Type :
- article
- Full Text :
- https://doi.org/10.5937/jomb0-45932