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D-galactose Intake Alleviates Atopic Dermatitis in Mice by Modulating Intestinal Microbiota

Authors :
Dong-Yeon Kim
Do-Hyeon Jung
Eun-Jung Song
Ah-Ra Jang
Ji-Yeon Park
Jae-Hun Ahn
Tae-Sung Lee
Yeong-Jun Kim
Yun-Ji Lee
In-Su Seo
Hye-Eun Kim
Eun-Ju Ryu
Jaehyun Sim
Jong-Hwan Park
Source :
Frontiers in Nutrition, Vol 9 (2022)
Publication Year :
2022
Publisher :
Frontiers Media S.A., 2022.

Abstract

Atopic dermatitis (AD) is one of the most prevalent, chronic and persistent inflammatory skin diseases closely associated with intestinal microbiota. To evaluate the effect of D-galactose intake on AD, we orally administered D-galactose to BALB/c mice whose ears and skin were treated with 2,4-dinitrochlorobenzene (DNCB). D-galactose alleviated DNCB-induced AD-like phenotypes such as redness, scaling/dryness and excoriation. Ear thickness was also decreased by D-galactose administration. Histopathological analysis revealed decreased epidermal thickening, infiltration of immune cells, especially mast cells, in the dermis. Total levels of serum IgE representing the immunological response of AD were decreased by D-galactose administration. Microbiota analysis showed that D-galactose administration restored gut microbiota profiles, which were altered in AD mice, characterized by increased abundance of Bacteroidetes and decreased abundance of Firmicutes. The increased abundance of Bacteroides and the decreased abundance of Prevotella and Ruminococcus were reversed by D-galactose treatment, following improvement of AD. Our results suggest the possible use of D-galactose as a prebiotic to alleviate AD by altering gut microbiota.

Details

Language :
English
ISSN :
2296861X
Volume :
9
Database :
Directory of Open Access Journals
Journal :
Frontiers in Nutrition
Publication Type :
Academic Journal
Accession number :
edsdoj.3118e048ac23467da9bfb2ae00ad26c9
Document Type :
article
Full Text :
https://doi.org/10.3389/fnut.2022.895837