SS-68 IMPACT ON THE CONTRACTIVE ACTIVITY OF ISOLATED VESSELS

In the experiments on isolated circular segments of the thoracic aorta of a rat it has been proved that indole SS-66 derivative in 10-5 and 10-4 М concentrations can relax smooth muscle cells (SMS) due to its impact on the SMS potassium conduction thus facilitating their hyperpolarization. It results in the block of voltage-sensitive calcium channels, the decrease in calcium input and the SMS relaxing. Lack of the NO-synthase Nω-nitro-L-arginine blocker impact on this process indicates of the lack of the SS-68 impact on the processes connected with the endothelium-dependant SMS relaxation.