Back to Search Start Over

Active-matrix digital microfluidics design for field programmable high-throughput digitalized liquid handling

Authors :
Dongping Wang
Kai Jin
Jiajian Ji
Chenxuan Hu
Maohua Du
Yacine Belgaid
Subao Shi
Jiahao Li
Siyi Hu
Arokia Nathan
Jun Yu
Hanbin Ma
Source :
iScience, Vol 27, Iss 5, Pp 109324- (2024)
Publication Year :
2024
Publisher :
Elsevier, 2024.

Abstract

Summary: Digital liquid sample handling is an enabling tool for cutting-edge life-sciences research. We present here an active-matrix thin-film transistor (TFT) based digital microfluidics system, referred to as Field Programmable Droplet Array (FPDA). The system contains 256 × 256 pixels in an active area of 10.65 cm2, which can manipulate thousands of addressable liquid droplets simultaneously. By leveraging a novel TFT device and circuits design solution, we manage to programmatically manipulate droplets at single-pixel level. The minimum achievable droplet volume is around 0.5 nL, which is two orders of magnitude smaller than the smallest droplet ever reported on active-matrix digital microfluidics. The movement of droplets can be either pre-programmed or controlled in real-time. The FPDA system shows great potential of the ubiquitous thin-film electronics technology in digital liquid handling. These efforts will make it possible to create a true programmable lab-on-a-chip device to enable great advances in life science research.

Subjects

Subjects :
Chemistry
Fluidics
Physics
Science

Details

Language :
English
ISSN :
25890042
Volume :
27
Issue :
5
Database :
Directory of Open Access Journals
Journal :
iScience
Publication Type :
Academic Journal
Accession number :
edsdoj.3086c9e2a51c4ecf8de02ae07e911175
Document Type :
article
Full Text :
https://doi.org/10.1016/j.isci.2024.109324