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Decoding lifespan secrets: the role of the gonad in Caenorhabditis elegans aging

Authors :
Andre Pires da Silva
Rhianne Kelleher
Luke Reynoldson
Source :
Frontiers in Aging, Vol 5 (2024)
Publication Year :
2024
Publisher :
Frontiers Media S.A., 2024.

Abstract

The gonad has become a central organ for understanding aging in C. elegans, as removing the proliferating stem cells in the germline results in significant lifespan extension. Similarly, when starvation in late larval stages leads to the quiescence of germline stem cells the adult nematode enters reproductive diapause, associated with an extended lifespan. This review summarizes recent advancements in identifying the mechanisms behind gonad-mediated lifespan extension, including comparisons with other nematodes and the role of lipid signaling and transcriptional changes. Given that the gonad also mediates lifespan regulation in other invertebrates and vertebrates, elucidating the underlying mechanisms may help to gain new insights into the mechanisms and evolution of aging.

Details

Language :
English
ISSN :
26736217
Volume :
5
Database :
Directory of Open Access Journals
Journal :
Frontiers in Aging
Publication Type :
Academic Journal
Accession number :
edsdoj.3080a2c8af524c529750562b2a9e26be
Document Type :
article
Full Text :
https://doi.org/10.3389/fragi.2024.1380016