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Efficacy of different doses and timing of tranexamic acid in major orthopedic surgeries: a randomized trial
- Source :
- Brazilian Journal of Anesthesiology, Vol 70, Iss 4, Pp 311-317 (2020)
- Publication Year :
- 2020
- Publisher :
- Elsevier, 2020.
-
Abstract
- Background: Tranexamic acid was studied in four different dosage regimens and their efficacy was compared for perioperative blood loss reduction, blood transfusion requirements and deep vein thrombosis (DVT) complication. Methods: Two hundred patients undergoing major orthopedic procedures were divided into five groups containing 40 patients each: Placebo, low dose (bolus 10 mg kg−1), low dose + maintenance (bolus 10 mg kg−1 + maintenance 1 mg kg−1 hr−1), high dose (bolus 30 mg kg−1) and high dose + maintenance (bolus 30 mg kg−1 + maintenance 3 mg kg−1 hr−1). Surgical blood loss was measured intraoperatively and drains collection in the first 24 hours postoperatively. Blood transfusion was done when hematocrit falls less than 25%. DVT screening was done in the postoperative period. Results: The intraoperative blood loss was 440 ± 207.54 mL in the placebo group, 412.5 ± 208.21 mL in the low dose group, 290 ± 149.6 ml in the low dose plus maintenance group, 332.5 ± 162.33 mL in the high dose group and 240.7 ± 88.15 mL in the high dose maintenance group (p
Details
- Language :
- English
- ISSN :
- 01040014
- Volume :
- 70
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Brazilian Journal of Anesthesiology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.305b1e8fbd9b4851b895fc885a843110
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.bjane.2020.06.008