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Solving neurodegeneration: common mechanisms and strategies for new treatments

Solving neurodegeneration: common mechanisms and strategies for new treatments

Authors :
Lauren K. Wareham
Shane A. Liddelow
Sally Temple
Larry I. Benowitz
Adriana Di Polo
Cheryl Wellington
Jeffrey L. Goldberg
Zhigang He
Xin Duan
Guojun Bu
Albert A. Davis
Karthik Shekhar
Anna La Torre
David C. Chan
M. Valeria Canto-Soler
John G. Flanagan
Preeti Subramanian
Sharyn Rossi
Thomas Brunner
Diane E. Bovenkamp
David J. Calkins
Source :
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-29 (2022)
Publication Year :
2022
Publisher :
BMC, 2022.

Abstract

Abstract Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic targets based on neuronal protection, repair, or regeneration, independent of etiology or site of disease pathology. To address these mechanisms and discuss emerging treatments, in April, 2021, Glaucoma Research Foundation, BrightFocus Foundation, and the Melza M. and Frank Theodore Barr Foundation collaborated to bring together key opinion leaders and experts in the field of neurodegenerative disease for a virtual meeting titled “Solving Neurodegeneration”. This “think-tank” style meeting focused on uncovering common mechanistic roots of neurodegenerative disease and promising targets for new treatments, catalyzed by the goal of finding new treatments for glaucoma, the world’s leading cause of irreversible blindness and the common interest of the three hosting foundations. Glaucoma, which causes vision loss through degeneration of the optic nerve, likely shares early cellular and molecular events with other neurodegenerative diseases of the central nervous system. Here we discuss major areas of mechanistic overlap between neurodegenerative diseases of the central nervous system: neuroinflammation, bioenergetics and metabolism, genetic contributions, and neurovascular interactions. We summarize important discussion points with emphasis on the research areas that are most innovative and promising in the treatment of neurodegeneration yet require further development. The research that is highlighted provides unique opportunities for collaboration that will lead to efforts in preventing neurodegeneration and ultimately vision loss.

Details

Language :
English
ISSN :
17501326
Volume :
17
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Molecular Neurodegeneration
Publication Type :
Academic Journal
Accession number :
edsdoj.304792ddb214075a9d068c15e1e5d12
Document Type :
article
Full Text :
https://doi.org/10.1186/s13024-022-00524-0