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Explicit interaction information from WikiPathways in RDF facilitates drug discovery in the Open PHACTS Discovery Platform [version 2; referees: 2 approved]

Authors :
Ryan A. Miller
Peter Woollard
Egon L. Willighagen
Daniela Digles
Martina Kutmon
Antonis Loizou
Andra Waagmeester
Stefan Senger
Chris T. Evelo
Source :
F1000Research, Vol 7 (2018)
Publication Year :
2018
Publisher :
F1000 Research Ltd, 2018.

Abstract

Open PHACTS is a pre-competitive project to answer scientific questions developed recently by the pharmaceutical industry. Having high quality biological interaction information in the Open PHACTS Discovery Platform is needed to answer multiple pathway related questions. To address this, updated WikiPathways data has been added to the platform. This data includes information about biological interactions, such as stimulation and inhibition. The platform's Application Programming Interface (API) was extended with appropriate calls to reference these interactions. These new methods of the Open PHACTS API are available now.

Details

Language :
English
ISSN :
20461402
Volume :
7
Database :
Directory of Open Access Journals
Journal :
F1000Research
Publication Type :
Academic Journal
Accession number :
edsdoj.3037cd61029b4da4a0e7b7123443baa6
Document Type :
article
Full Text :
https://doi.org/10.12688/f1000research.13197.2